Use the PICO format to help formulate the question:
P What is the Patient, Population, or Problem?
I What Interventions are being considered?
C What is the Comparison?
O What are the Outcomes of interest?
Determine: What study designs are appropriate to answer this question? (2, 4)
"PICO is basically a statement on the inclusion and exclusion criteria. Too broad a question may result in an unmanageable number of studies to be included and analysed, and too narrow a question may yield no studies at all." (4)
See the LibGuide,
2. Haase, S. (2011). Systematic Reviews and Meta-analysis. Plastic and Reconstructive Surgery, 127(2), 955-966. PMID: 21285802
4. Sambunjak, D., & Franic, M. (2012). Steps in the undertaking of a systematic review in orthopaedic surgery. International Orthopaedics, 36(3), 477-84.